Medical Writing Medical Writing in Oncology The Webscout
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Volume 21, Issue 1 - Medical Writing in Oncology

The Webscout

Abstract

Cannabinoids in oncology: more than a palliative

Usually you have chemotherapeutics and biologicals in mind when you are talking about oncology. Would you have thought of cannabinoids? I don't think so but for decades, cannabinoids have been known to exert palliative effects in cancer patients including appetite stimulation and pain relief.1,2

References

  1. Glare P, Miller J, Nikolova T, Tickoo R. Treating nausea and vomiting in palliative care: a review. Clin Interv Aging 2011;6:243–59.
  2. Farquhar-Smith WP. Do cannabinoids have a role in cancer pain management? Curr Opin Support Palliat Care 2009;3:7–13.
  3. Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006;58:389–462.
  4. Munson A, Harris L, Friedman M, Dewey W, Carchman R. Antineoplastic activity of cannabinoids. J Natl Cancer Inst 1975;55:597–602.
  5. Sanchez C, Galve-Roperh I, Canova C, Brachet P, Guzman M. Δ9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Lett 1998;436:6–10.
  6. Jacobsson S, Wallin T, Fowler C. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 2001;299:951–9.
  7. Galve-Roperh I, Sanchez C, Cortes M, del Pulgar T, Izquierdo M, Guzman M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000;6:313–9.
  8. Casanova M, Blazquez C, Martinez-Palacio J, Villanueva C, Fernandez-Acenero M, Huffman J, et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003;111:43–50.
  9. Blazquez C, Gonzalez-Feria L, Alvarez L, Haro A, Casanova M, Guzman M. Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 2004;64:5617–23.
  10. Blazquez C, Casanova M, Planas A, Pulgar TD, Villanueva C, Fernandez-Acenero M, et al. Inhibition of tumor angiogenesis by cannabinoids. FASEB J 2003;17:529–31.
  11. Ramer R, Hinz B. Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 2008;100:59–69.
  12. Ramer R, Merkord J, Rohde H, Hinz B. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol 2010;79:955–66.
  13. Bifulco M, Laezza C, Valenti M, Ligresti A, Portella G, DiMarzo V. A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. FASEB J 2004;18:1606–8.
  14. Petrocellis LD, Melck D, Palmisano A, Bisogno T, Laezza C, Bifulco M, et al. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc Natl Acad Sci USA 1998;95:8375–80.
  15. Sarker K, Maruyama I. Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts. Cell Mol Life Sci 2003;60:1200–8.
  16. Portella G, Laezza C, Laccetti P, Petrocellis LD, Marzo VD, Bifulco M. Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J 2003;17:1771–3.
  17. Guzman M, Duarte M, Blazquez C, Ravina J, Rosa M, Galve-Roperh I, et al. A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br J Cancer 2006;95:197–203.
  18. Guzman M. Cannabinoids: potential anticancer agents. Nat Rev Cancer 2003;3:745–55.
  19. Pertwee RG. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol 2009;156:397–411.
  20. Bifulco M, DiMarzo V. Targeting the endocannabinoid system in cancer therapy: a call for further research. Nat Med 2002;8:547–50.
  21. Freimuth N, Ramer R, Hinz B. Antitumorigenic effects of cannabinoids beyond apoptosis. J Pharmacol Exp Ther 2010;332:336–44.
  22. Leydon GM, Moynihan C, Boulton M, Mossman J, Boudioni M, McPherson K. Cancer patients' information needs and information seeking behaviour: in depth interview study. BMJ 2000;320:909–13.
  23. McKenzie J. Similar study had similar findings. Letters to the editor. BMJ 2000;321:632.
  24. Hoppe IC. Readability of patient information regarding breast cancer prevention from the Web site of the National Cancer Institute. J Cancer Educ 2010;25(4):490–2.
  25. Meredith C, Symonds P, Webster L, Lamont D, Pyper E, Gillis CR, et al. Information needs of cancer patients in west Scotland: cross sectional survey of patients’ views. BMJ 1996;313(7059):724–6.
  26. Thomsen OO, Wulff HR, Martin A, Singer PA. What do gastroenterologists in Europe tell cancer patients? Lancet 1993;341(8843):473–6.
  27. Evan D. Survey: Israeli doctors withhold information from cancer patients. Haaretz 2011;92(28148):1–2.
  28. The NHS Cancer plan: a plan for investment, a plan for reform. Department of Health. 2000 Available from: http://www.cancerinfo.nhs.uk/images/stories/docs/cancer_plan_2000.pdf
  29. Mayer DK, Terrin NC, Kreps GL, Menon U, McCance K, Parsons SK, et al. Cancer survivors information seeking behaviors: a comparison of survivors who do and do not seek information about cancer. Patient Educ Couns 2007;65(3):342–50.
  30. Hewitt M, Greenfield S, Stovall E, (eds.) From cancer patient to cancer survivor: lost in transition. Committee on Cancer Survivorship: Improving Care and Quality of Life, Institute of Medicine and National Research Council. 2006. Washington D.C., USA: National Academies Press. Available from: http://www.nap.edu/catalog/11468.html.
  31. Centers for Disease Control and Prevention (CDC). Cancer survivors—United States, 2007. MMWR. 2011;60(9):269–272.
  32. Glaser A. Introduction: a new approach. Health Serv J 2011;2(supplement). Available from: http://www.ncsi.org.uk/wp-content/uploads/HSJ_survivorship_supplement.pdf
  33. Wolf SN, Nichols C, Ulman D, et al. Survivorship: an unmet need of the patient with cancer—implications of a survey of the Lance Armstrong Foundation (abstract). J Clin Oncol 2005 ASCO Annual Meeting Proceedings; 23(16S), Part I of II (June 1 Supplement): 6032. Available from: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=34&abstractID=31848.

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Message from the President
The war on cancer – What is the enemy, and are we winning?
Medical writing for cancer trials and submissions
Developing a treatment for ovarian cancer
The evolving landscape of medical education in oncology
Some considerations on the safety evaluation section of clinical study reports for studies with anticancer drugs
Identifying appropriate journals in which to publish original research on vaccines against human infectious diseases
New myths about English
From researcher in Europe to medical writer in India
Imaging techniques in oncology
Is cancer preventable? A literature review
A rising tide: Hospitals and social media
In the Bookstores
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