Medical Writing Obesity and Type 2 Diabetes Genetics and environmental factors in obesity and diabetes: Complex problems, complex solutions

Volume 21, Issue 4 - Obesity and Type 2 Diabetes

Genetics and environmental factors in obesity and diabetes: Complex problems, complex solutions


Over the centuries people have become taller, heavier, and stronger. One of the major reasons for this is the increasing supply of calories in our diets. In earlier times, weight gain was extremely beneficial for health, well-being, and lifespan, but in 2012 we are at a point where weight gain has gone too far and is now detrimental. We are facing an overeating epidemic and the adverse health effects of obesity. This article discusses some of the causes of obesity and the factors affecting it.

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  1. World Health Organization. Health topics: obesity. Available from:
  2. World Health Organization. World Health Statistics 2012: new data highlight increases in hypertension, diabetes incidence. Available from:
  3. Kopelman PG. Obesity as a medical problem. Nature 2000;404:635–43.
  4. Guo SS, Chumlea WC. Tracking of body mass index in children in relation to overweight in adulthood. Am J Clin Nutr 1999;70:S145–8.
  5. Freedman DS, Khan LK, Dietz WH, Srinivasan SA, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics 2001;108:712–8.
  6. World Health Organization. WHO Global Infobase Available from:
  7. Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet 2011;378:804–14.
  8. Popkin BM. Sugary beverages represent a threat to global health. Trends Endocrinol Metab 2012; [Epub ahead of print]. PMID:22867870.
  9. Centers for Disease Control and Prevention. Overweight and obesity: causes and consequences. Available from:
  10. Story M, Kaphingst KM, Robinson-O'Brien R, Glanz K. Creating healthy food and eating environments: policy and environmental approaches. Annu Rev Public Health 2008;29:253–72.
  11. Heindel JJ, vom Saal FS. Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the etiology of obesity. Mol Cell Endocrinol 2009;304:90–6.
  12. Heitmann BL, Westerterp KR, Loos RJ, Sørensen TI, O'Dea K, Mc Lean P, et al. Obesity: lessons from evolution and the environment. Obes Rev 2012;13:910–22.
  13. Miyawaki J, Sakayama K, Kato H, Yamamoto H, Masuno H. Perinatal and postnatal exposure to bisphenol A increases adipose tissue mass and serum cholesterol level in mice. J Atherscler Thromb 2007;14:245–52.
  14. Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 2008;300:1303–10.
  15. Trasande L, Blustein J, Liu M, Corwin E, Cox LM, Blaser MJ. Infant antibiotic exposures and early-life body mass. Int J Obes (Lond) 2012; [Epub ahead of print]. doi: 10.1038/ijo.2012.132.
  16. Ali AT, Crowther NJ. Factors predisposing to obesity: a review of the literature. JEMDSA 2009;14:81–4.
  17. Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 1997;27:325–51.
  18. Rose KM, Newmann B, Mayer-Davis EJ, Selby JV. Genetic and behavioural determinants of waist-hip ratio and waist circumference in women twins. Obes Res 1998;6:383–92.
  19. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–32.
  20. Hall SS. The genes we share: a report from the Howard Hughes Medical Institute: discovering the obesity genes. Available from:
  21. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903–8.
  22. Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;398:398–401.
  23. Speliotes EK. The genetic determinants of common human obesity. Curr Cardiovasc Risk Rep 2009;3:411–7.
  24. O'Rahilly S, Farooqi IS. Genetics of obesity. Philos Trans R Soc Lond B Biol Sci 2006;361:1095–105.
  25. Loos RJF. The genetic determinants of common obesity-susceptibility. In: Symonds ME, (ed.) Adipose tissue biology. New York: Springer Science; 2012. p. 317–78.
  26. Loos RJ. Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab 2012;26:211–26.
  27. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249 796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010;42:937–48.
  28. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997;337:869–73.
  29. Williams MJ, Almén MS, Fredriksson R, Schiöth HB. What model organisms and interactomics can reveal about the genetics of human obesity. Cell Mol Life Sci 2012;69:3819–34.
  30. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889–94.
  31. Ren D, Li M, Duan C, Rui L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab 2005;2:95–104.
  32. Hagberg JM, Rankinen T, Loos RJ, Pérusse L, Roth SM, Wolfarth B, et al. Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exerc 2011;43:743–52.
  33. O'Dea K. Traditional diet and food preferences of Australian aboriginal hunter-gatherers. Philos Trans R Soc Lond B Biol Sci 1991;334:233–40; discussion 240–1.
  34. Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab 2004;89:2583–9.
  35. Singh-Manoux A, Czernichow S, Elbaz A, Dugravot A, Sabia S, Hagger-Johnson G, et al. Obesity phenotypes in midlife and cognition in early old age: The Whitehall II cohort study. Neurology 2012;79:755–62.
  36. Burkhalter TM, Hillman CH. A narrative review of physical activity, nutrition, and obesity to cognition and scholastic performance across the human lifespan. Adv Nutr 2011;2:201S–6S.
  37. Barness LA, Opitz JM, Gilbert-Barness E. Obesity: genetic, molecular, and environmental aspects. Am J Med Genet A 2007;143A(24):3016–34.
  38. Centers for Disease Control and Prevention. Overweight and obesity: adult obesity facts Available from:
  39. Department of Health. Public health, adult social care and the NHS. Obesity. Available from:
  40. International Diabetes Federation. IDF diabetes atlas – Fifth Edition. Available from:
  41. World Health Organization. Health topics: diabetes. Available from:
  42. Diabetes UK. Care. Connect. Campaign. Available from:
  43. Centers for Disease Control and Prevention. Healthy people 2010: final review: nutrition and overweight. Available from:



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In the Bookstores
Journal Watch
The Webscout
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Medical Journalism
Out On Our Own

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