Medical Writing Statistics History of biostatistics

Volume 25, Issue 3 - Statistics

History of biostatistics


The history of biostatistics could be viewed as an ongoing dialectic between continuity and change. Although statistical methods are used in current clinical studies, there is still ambivalence towards its application when medical practitioners treat individual patients. This article illustrates this dialectic by highlighting selected historical episodes and methodological innovations – such as debates about inoculation and blood - letting, as well as how randomisation was introduced into clinical trial design. These historical episodes are a catalyst to consider assistance of non-practitioners of medicine such as statisticians and medical writers.

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  1. The Internet Classics Archive. On Airs, Waters, and Places by Hippocrates. 2016. [cited 2016 June 30]. Available from:
  2. Collier R. Legumes, lemons and strep - to mycin: A short history of the clinical trial. CMAJ. 2009;180(1): 23-4.
  3. Rusnock AA. Vital accounts: Quantifying health and population in eighteenth-century England and France. Cambridge: Cambridge University Press; 2002.
  4. Louis PCA. Researchers on the effects of bloodletting in some inflammatory diseases, and on the Influence of tartarized antimony and vesication in pneumonitis. Putnam CG, translator. Boston: Hilliard, Gray; 1836.
  5. Risueño d’Amador B. Memoire sur le calcul des probabilites applique a la medicine. Montpellier: L.F. Gaste; 1838.
  6. Bulletin de l’Académie Royale de Médecine. 1836/37; 1: 702.
  7. Gavarret J. Principes généraux de statistique médicale. Paris: Libraires de la Faculté de Médecine de Paris; 1840.
  8. Tröhler U. Statistics and the British controversy about the effects of Joseph Lister’s system of antisepsis for surgery, 1867-1890. JLL Bulletin: Commentaries on the history of treatment evaluation. 2016 [cited 2016 June 30]. Available from:
  9. Hardy A, Magnello ME. Statistical methods in epidemiology: Karl Pearson, Ronald Ross, Major Greenwood and Austin Bradford Hill, 1900-1945. Soziologie- Präventivmedizin. 2002; 47: 80–9.
  10. Magnello E. The introduction of mathematical statistics into medical research: The roles of Karl Pearson, Major Greenwood, and Austin Bradford Hill. In: Magnello E, Hardy A, editors. The road to medical statistics. Amsterdam-New York: Rodopi; 2002. p. 95-123.
  11. Matthews JR. Almroth Wright, vaccine therapy, and British biometrics: Disciplinary expertise versus statistical objectivity, In: Magnello E, Hardy A, editors. The road to medical statistics. Amsterdam-New York: Rodopi; 2002. p. 125-147.
  12. Farewell V, Johnson T. Major Greenwood (1880–1949): A biographical and bibliographical study. Stat Med. 2016;35:645–70.



Statistics for medical writers
President's Message
History of biostatistics
The illusion of certainty and the certainty of illusion
Never P alone: The value of estimates and confidence intervals
A medical writer's guide to meta-analysis
Study design made easy
Statistical analyses and methods in the published literature: The SAMPL guidelines
How to interpret and report the results from multivariable analyses
Biostatistics and medical writing: Synergy in preparing clinical trials documents
Best friends forever: A pattern of collaboration between medical writers and biostatisticians within the Russian CRO
Where have all the UK entry level pharmaceutical regulatory medical writing jobs gone?
News from the EMA
Journal Watch
In the Bookstores
The Webscout
Good Writing Practice
Medical Communications
Getting Your Foot in the Door
Lingua Franca and Beyond
Gained in Translation
Teaching Medical Writing
Profile: An interview with Professor Peter Jüni on methodology and statistics in scientific manuscripts
Out On Our Own


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