Medical Writing Visual Communications Enhancing accessibility of study data: The development of a graphical abstract for lay summaries of clinical trial results

Volume 29, Issue 1 - Visual Communications

Enhancing accessibility of study data: The development of a graphical abstract for lay summaries of clinical trial results


 We describe the development of a graphical abstract for lay summaries of clinical trial results. The new graphical summary serves the same purpose for a lay summary as an abstract does for a scientific publication. Lay summaries are intended to inform the general public about the results of clinical studies. Consequently, they need to be understandable to people without specific knowledge of the disease or knowledge of the clinical research process. Visual displays have been shown to greatly support the under standing of complex data. With the support of patient organisations, we first determined the information items that were to be included in the graphical abstract and then transformed them into visual representations on a single page preceding the lay summary. Review and feedback from stakeholders and patient representatives helped derive a final graphical abstract template for all lay summaries across therapeutic areas. The generally positive feedback from patient representatives emphasises the usefulness of the graphical abstract in conveying key information of clinical trials.

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  1. Regulation (EU) No 536/2014 of the European Parliament and of the Council of 16 April 2014 on clinical trials on medicinal products for human use, and repealing Directive 2001/20/EC (Text with EEA relevance). Available from: EN/TXT/?uri=uriserv:OJ.L_.2014.158.
  2. Sroka-Saidi K, Boggetti B, Schindler TM. Transferring regulation into practice: The challenges of the new layperson summary of clinical trial results. Med Writ. 2015;24(1):247.
  3. Brauburger K, Sroka-Saidi K, Schindler TM. New European clinical trial regulation: The requirement for lay summaries and its impact on medical communicators. Amer Med Writers Assoc J. 2015;30(2): 60–3. 4. Summaries of clinical trial results for laypersons; recommendations of the expert group on clinical trials for the implementation of Regulation (EU) No 536/2014 on clinical trials on medicinal products for human use. Version 2, date of publication 22 February 2018. Available from: sites/health/files/files/eudralex/vol- 10/2017_01_26_summaries_of_ct_ results_for_laypersons.pdf.
  4. OECD Literature in the information age: Final report of the International Adult literacy Survey (IALS), 2000. Available from: http://www.oecd/edu/skillsbeyond- school/41529765.pdf.
  5. Kirsch IS. The International Adult Literacy Survey (IALS): Understanding what was measured. 2001 Available from: pdf/RR-01-25-Kirsch.pdf.
  6. Rampey BD, Finnegan R, Goodman M, Mohadjer L, Krenzke T, Hogan J et al. Skills of U.S. unemployed, young, and older adults in sharper focus: Results From the Program for the International Assessment of Adult Competencies (PIAAC) 2012/2014: First look (NCES 2016-039). U.S. Department of Education. Washington, DC: National Center for Education Statistics 2016 Available from:
  7. Katz MG, Kripalani S, Weiss BD. Use of pictorial aids in medication instructions: A review of the literature. Am J Health-Syst Pharm. 2006;63:2391-2397.
  8. Mohan A, Riley B, Boyington D, Kripalani S. PictureRx: Illustrated medication Instructions for patients with limited health literacy, J Am Pharm Assoc. 2012;52(5):e122–9.
  9. Berthenet M, Vaillantcourt R, Pouliot A. Evaluation, modification, and validation of pictograms depicting medication instructions in the elderly. J Health Comm. 2016;21(S1):27–33.
  10. National Academies of Sciences, Engineer ing, and Medicine. Communicating clearly about medicines: Proceedings of a workshop. Washington, DC: The National Academies Press 2017. Available from:
  11. Leithold LHE, Brown CM, Schindler TM. Lay titles for clinical trials: A balancing act. Med Writ. 2018;27(2):55–8.



President's Message
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Enhancing accessibility of study data: The development of a graphical abstract for lay summaries of clinical trial results
Connecting medical writers in Portugal through visual communication
Clinical trial design: Considerations for medical writers developing clinical trial protocols
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Regulatory Matters
News from the EMA
Journal Watch
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Veterinary Medical Writing
Good Writing Practice
Medical Writing Humour
Out on our Own


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