Volume 27, Issue 1 - Vaccines and Immunotherapies

HIV vaccine clinical trials: An overview

Author: Jackline Odhiambo

Abstract

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References

1. Hiv.gov. HIV Vaccines. 2017 [cited 2017 Nov 11]. Available from: https://www.hiv.gov/hiv-basics/hiv-prevention/potential-future-options/hiv-vaccines
2. Kurth AE, Celum C, Baeten JM, Vermund SH, Wasserheit JN. Combination HIV prevention: significance, challenges, and opportunities. Current HIV/AIDS reports. 2011;8(1):62–72.
3. Stover J, Bollinger L, Hecht R, Williams C, Roca E. The impact of an AIDS vaccine in developing countries: a new model and initial results. Health Aff. 2007;26(4):1147–58.
4. Sheets RL, Zhou T, Knezevic I. Review of efficacy trials of HIV-1/AIDS vaccines and regulatory lessons learned: a review from a regulatory perspective. Biologicals. 2016;44(2):73–89.
5. The History of Vaccines: An Educational Resource by The College of Physicians of Philadelphia. Vaccines for Sexually Transmitted Diseases. 2017 [cited 2017 Nov 11]. Available from: https://www. historyofvaccines.org/content/articles/ vaccines-sexually-transmitted-diseases
6. Follmann D, Duerr A, Tabet S, Gilbert P, Moodie Z, Fast P, et al. J Acquir Immune Defic Syndr. 2007;44(1):49–60.
7. HIV/AIDS vax - An IAVI Report Bulletin. Understanding Vaccine Trials: How are AIDS vaccines tested? 2003;1(1):4. Available from: http://www.vaxreport.org/vax-1-1-august- 2003/869-understanding-vaccine-trials.
8. Esparza J. An HIV vaccine: how and when? Bull World Health Organ. 2001;79(12):1133–7.
9. The History of Vaccines: An Educational Resource by The College of Physicians of Philadelphia. Vaccine Development, Testing, and Regulation. 2017 [cited 2017 Nov 04] Available from: https://www.historyofvaccines.org/content/articles/vaccine-development-testing-and-regulation
10. Black S. The costs and effectiveness of large Phase III pre-licensure vaccine clinical trials. Expert Rev Vaccines. 2015;14(12):1543–8.
11. Wu X, Wang C, O’Dell S, Li Y, Keele BF, Yang Z, et al. Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site. J Virol. 2012;86(10):5844–56.
12. AMP Study. About AMP: What is the AMP Study? 2017 [cited 2017 Nov 30]. Available from: https://ampstudy.org.za/about
13. U.S. Military HIV Research Program. RV144 Trial. 2017 [cited 2017 Dec 02]. Available from: https://www.hivresearch.org/rv144-trial
14. Uhambo: A Journey of Hope to Prevent HIV. What is HVTN 702? 2017 [cited 2017 Nov 30]. Available from: http://www.uhambo.org.za/about
15. Imbokodo: Stand up to HIV. What is Imbokodo? 2017 [cited 2017 Nov 30]. Available from: https://www.imbokodo.org.za/about
16. Vardas E, Buttò S, Glashoff R, Malnati MS, Poli G, Clerici M. Preparing for phase II/III HIV vaccine trials in Africa. Microbes Infect. 2005;7(14):1436–44.
17. UNAIDS Guidance Document: Ethical considerations in HIV preventive vaccine research. 2000
18. Scientific considerations for the regulation and clinical evaluation of HIV/AIDS preventive vaccines: report from a WHOUNAIDS Consultation 13-15 March 2001, Geneva, Switzerland. AIDS. 2002;16(10):W15–25.
19. Okpokoro E, Osawe S, Datong P, Yakubu A, Ukpong M, Orhii P, et al. Preparing for HIV vaccine trials in Nigeria: building the capacity of the community and national coordinating, regulatory and ethical bodies. J AIDS Clin Res. 2013;4(12):260.
20. National Institute of Environmental Health Sciences. Institutional Biosafety Committee. 2017 [cited 2017 Dec 03]. Available from: https://www.niehs.nih.gov/about/boards/ibc/index.cfm
21. Department of Agriculture, Forestry and Fisheries: Republic of South Africa. Biosafety Notifications. 2017 [cited 2017 Dec 03]. Available from: http://www.daff.gov.za/daffweb3/Branches/Agricultural-Production-Health-Food-Safety/Genetic-Resources/Biosafety/Biosafety-Clearing-House
22. Barouch DH, Picker LJ. Novel vaccine vectors for HIV-1. Nat Rev Microbiol. 2014;12(11):765–71.
23. Excler JL, Michael NL. Lessons from HIV- 1 vaccine efficacy trials. Curr Opin HIV AIDS. 2016;11(6):607–13.
24. HIV Vaccine Trials Network. Getting the Right Test for HIV. [cited 2017 Nov 30]. Available from: http://www.hvtn.org/en/participants/visp-hiv-testing.html