You are very welcome to this special edition of Medical Writing where the focus is on patient-reported outcomes (PROs). This is my second time to act as a guest editor. Once again, in the process of putting the issue together, I was highly impressed by the breadth and level of knowledge possessed by EMWA members. My sincere thanks to everyone who has contributed to this issue in whatever form. It really was a joy to work with you all – as well as being very educational. The end result is that whether you are new to the topic or a seasoned PRO pro(!), there is something for everyone in this issue.